The answer is that it completely depends on the towelettes—and on the face wash you're used to as well. Cleansing wipes are just as varied as traditional cleansers, so you should think about what makes a cleanser worthwhile or effective for you, then find a portable cloth version of that. If acne control and oiliness are issues for you, something like The Body Shop Tea Tree Cleansing Wipes would probably be a good match. On the other hand, if brightening or exfoliating cleansers are your favorites, a product along the lines of Ole Henriksen The Clean Truth Cleansing Cloths might deliver better results. And if you're a simple Cetaphil and water fan, try a gentle version like Pond's Original Fresh Wet Cleansing Towelettes.
Have another favorite? Do tell.